Anticlastogenic Effects of Ascorbic Acid Against the Genotoxic Damage Induced by Norethynodrel

Ascorbic acid is well known antioxidant. The antioxidant property can be helpful in reducing clastogenic, mutagenic and carcinogenic properties of certain chemical agents. In this context, an anticlastogenic activity of ascorbic was studied against the genotoxic damage induced by norethynodrel, using chromosomal aberrations and sister chromatid exchanges as parameters. The treatments of different doses of ascorbic acid along with norethynodrel results in a significant decrease in the genotoxic damage. Since the prolonged used of oral contraceptives and synthetic steroids have been reported to develop various types of cancers. The natural antioxidants can form a good base in ameliorating the genotoxic effects of synthetic steroids during the therapy in patients, there by reducing the chances of carcinogenesis.